Barbara Wirthl, M.Sc.

Research interests
Publications in peer-reviewed journals

Wirthl B., Janko C., Lyer S., Schrefler B. A., Alexiou C., Wall W. A. (2024), An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow, Biomedical Microdevices, 26(1). doi:10.1007/s10544-023-00685-9

Wirthl B.*, Hervas-Raluy S.*, Enrique Guerrero P., Robalo Rei G., Nitzler J., Coronado E., Font de Mora J., Schrefler B. A., Gomez-Benito M. J., Garcia-Aznar J. M., Wall W.A. (2023), Tumour growth: An approach to calibrate parameters of a multiphase porous media model based on in vitro observations of Neuroblastoma spheroid growth in a hydrogel microenvironment, Computers in Biology and Medicine, 106895. doi:10.1016/j.compbiomed.2023.106895 (*co-first authorship)

Wirthl B., Brandstaeter S., Nitzler J. Schrefler B.A., Wall W.A. (2022), Global sensitivity analysis based on Gaussian-process metamodelling for complex biomechanical problems, Int J Numer Meth Biomed Engng., 39(3):e3675. doi:10.1002/cnm.3675

Wirthl B.*, Kremheller J.*, Schrefler B.A., Wall W. A. (2020), Extension of a multiphase tumour growth model to study nanoparticle delivery to solid tumours, PLOS ONE, 15(2):e0228443, doi:10.1371/journal.pone.0228443 (*co-first authorship)

Fletcher, T.L., Wirthl, B., Kolias, A.G. et al. (2016), Modelling of Brain Deformation After Decompressive Craniectomy. Ann Biomed Eng 44, 3495–3509, doi:10.1007/s10439-016-1666-7


Wirthl B., Wirthl V., Wall W. A. (2023), An efficient computational model of the in-flow cpaturing of magnetic nanoparticles by a cylindrical magnet for cancer nanomedicine, Preprint arXiv:2310.01103v1 [physics.comp-ph], doi:10.48550/arXiv.2310.01103

Supervised Student Projects 
  • Computational modelling of angiogenesis governed by the tumour microenvironment, Master's Thesis
  • Computational modelling of interactions between interstitial fluid flow and angiogenesis in solid tumours, Term Paper
  • Computational Modelling of in Vitro Tumour Growth: From Imaging Data to Bayesian Inverse Analysis, Term Paper
  • A Bayesian Inference Approach for Optimal Tumour Treatment Using Gaussian Processes, Term Paper (co-supervised with Jonas Nitzler)
  • A study of pharmacokinetics and pharmacodynamics in a multiphase tumour growth model, MSE research internships (co-supervised with Johannes Kremheller)
  • 3D Visualisation of tumour growth, Visualization Techniques in Computational Mechanics
  • Output Monitoring Routines for Parameter Studies in a Finite Element Tumour Growth Model, Bachelor's Thesis (co-supervised with Johannes Kremheller)
  • since 2018 Research Associate at the Institute for Computational Mechanics (Lehrstuhl für Numerische Mechanik), Technische Universität München, Germany
  • 2018 Master of Science (M.Sc.), Mechanical Engineering, Technische Universität München, Germany

3D Visualisation of a solid tumour with nanoparticles (Visualization Techniques in Computational Mechanics)